Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma
نویسندگان
چکیده
Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis, endocrinopathies and nephritis. Here, we report a case of a 75-year-old man with metastatic malignant melanoma treated with a combination of nivolumab (anti-PD1-antibody) and ipilimumab (anti-CTLA-4 antibody) who developed systemic rash along with severe acute tubulointerstitial nephritis after two doses of combination therapy. Kidney biopsy and peripheral blood immune profile revealed highly proliferative and cytotoxic T cell features. Herein, we discuss the pathophysiology and management of immune checkpoint blockade-related adverse events.
منابع مشابه
Interstitial nephritis in melanoma patients secondary to PD-1 checkpoint inhibitor
BACKGROUND Immune checkpoint inhibitors have become the first line therapy in melanoma treatment and their use is extending to other malignancies. However, we are still learning about immune side effects produced by these drugs and their severity especially in patients with history of inflammatory diseases. CASE PRESENTATION We present two cases of metastatic melanoma treated with nivolumab a...
متن کاملAcute interstitial nephritis after sequential ipilumumab - nivolumab therapy of metastatic melanoma
BACKGROUND The anti-Programmed Death receptor 1 (anti-PD-1) antibodies nivolumab and pembrolizumab are new treatments in metastatic melanoma. Immunotherapies are best known to be responsible for thrombotic microangiopathy. However, immune interstitial nephritis has been described in a patient treated by nivolumab and ipilimumab concomitantly, and three cases of granulomatous interstitial nephri...
متن کاملExacerbation of Psoriasis During Nivolumab Therapy for Metastatic Melanoma.
© 2016 The Authors. doi: 10.2340/00015555-2212 Journal Compilation © 2016 Acta Dermato-Venereologica. ISSN 0001-5555 Programmed cell death (PD)-1 is an immune checkpoint receptor expressed on antigen-stimulated T cells. Several types of anti-PD-1 antibodies have demonstrated a remarkable benefit for metastatic melanoma, with a low incidence of severe adverse events. A fully human antiPD-1 antib...
متن کاملPembrolizumab for Treatment of Patients with Advanced or Unresectable Melanoma.
From Coley's toxin to combination immune checkpoint inhibition, strategies to activate the immune system and generate anticancer immunity have been ongoing for well over a century. Over the past decade, the so-called immune checkpoint inhibitors, generally monoclonal antibodies that target key regulators of T-cell activation, emerged as the most effective immune-targeted agents. Pembrolizumab i...
متن کاملنفریت بینابینی حاد ناشی از پنتوپرازول: گزارش موردی
Pantoprazole is a proton-pump inhibitor that is commonly prescribed for the treatment of gastroesophageal reflux-related disorders. Acute interstitial nephritis is an uncommon though important side-effect of these classes of drugs. We reported a case with acute interstitial nephritis due to pantoprazole. A 25-year-old woman from Ardabil was admitted to our hospital with the complaint of fever, ...
متن کامل